HCST Gene Summary [Human]
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HCST |
| Official Name | hematopoietic cell signal transducer [Source:HGNC Symbol;Acc:HGNC:16977] |
| Ensembl ID | ENSG00000126264 |
| Bio databases IDs | |
| Aliases | hematopoietic cell signal transducer, DNAX-activation protein 10, kinase assoc pro of ~10kDa |
| Synonyms | DAP10, haematopoietic cell signal transducer, hematopoietic cell signal transducer, KAP10, PIK3AP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoinositide 3-kinase binding
- cytoplasmic domain
- DAP10 membrane protein
- transmembrane domain
- protein binding activity, bridging
- intracellular domain
- protein binding
- receptor binding
- transmembrane receptor
- Grb2 binding domain
Pathways
Biological processes and signaling networks where the HCST gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atherosclerosis
- insulin-dependent diabetes mellitus
- androgenic alopecia
- osteopetrosis
- experimental autoimmune encephalomyelitis
- ascites
role in cell
- apoptosis
- cytotoxicity
- activation in
- cell death
- phosphorylation in
- expression in
- number
- proliferation
- function
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- natural killer cell mediated cytotoxicity
- protein phosphorylation
- positive regulation of protein kinase B signaling cascade
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein binding
- receptor binding
- protein binding, bridging