PTP4A1 Gene Summary [Human]
This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | PTP4A1 |
| Official Name | protein tyrosine phosphatase 4A1 [Source:HGNC Symbol;Acc:HGNC:9634] |
| Ensembl ID | ENSG00000112245 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase 4A1, phosphatase of regenerating liver 1 |
| Synonyms | C130021B01, HH72, LOC100360241, LOC102547074, LOC103693189, PRL-1, PRL-CAAX1, protein tyrosine phosphatase 4A1, Ptp4a1 1, PTPCAAX1, PTP(CAAX1) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTP4A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Dual specificity phosphatase, catalytic domain
- protein-tyrosine-phoshatase
- catalytic domain
- phosphatase
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- farnesylation site
- PTPase domain
Pathways
Biological processes and signaling networks where the PTP4A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- chronic lymphocytic leukemia
- epileptic seizure
- androgenic alopecia
- psoriasis
- endometriosis
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- lung squamous cell carcinoma
role in cell
- motility
- proliferation
- migration
- expression in
- activation in
- signaling in
- binding in
- mitosis
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- spindle apparatus
- perinuclear region
- Plasma Membrane
- endosomes
- centrosome
- Endoplasmic Reticulum
- centriole
- cytoplasmic face of plasma membrane
- spindle fibers
- early endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTP4A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- cytoplasm
- spindle
- endoplasmic reticulum
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity