GAST Gene Summary [Human]
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GAST |
| Official Name | gastrin [Source:HGNC Symbol;Acc:HGNC:4164] |
| Ensembl ID | ENSG00000184502 |
| Bio databases IDs | |
| Aliases | gastrin, preprogastrin |
| Synonyms | GAS, GASTRIN, Gastrin-17, PPG34 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gastrin/cholecystokinin family
- hormone
- protein binding
- ATPase-binding domain
Pathways
Biological processes and signaling networks where the GAST gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cholecystokinin/Gastrin-mediated Signaling
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Gap Junction Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- JAK/Stat Signaling
- Molecular Mechanisms of Cancer
- Relaxin Signaling
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperplasia
- anemia
- splenomegaly
- gastric cancer
- pancreatic neoplasia
- pancreatic neoplasm
- obesity
- hyperglycemia
- thrombocytosis
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- binding in
- growth
- activation in
- production in
- adhesion
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Plasma Membrane
- nerve ending
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- G-protein coupled receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity