ATP4A Gene Summary [Human]
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ATP4A |
| Official Name | ATPase H+/K+ transporting subunit alpha [Source:HGNC Symbol;Acc:HGNC:819] |
| Ensembl ID | ENSG00000105675 |
| Bio databases IDs | |
| Aliases | ATPase H+/K+ transporting subunit alpha, gastric H,K-ATPase alpha subunit, H(+)-K(+)-ATPase alpha subunit, proton pump |
| Synonyms | ATP6A, ATPase, H+/K+ exchanging, gastric, alpha polypeptide, ATPase, H+/K+ exchanging, gastric, α polypeptide, Atpase, h+/k+ transporting, alpha polypeptide, ATPase H+/K+ transporting subunit alpha, ATPase H+/K+ transporting subunit α, Atpase, h+/k+ transporting, α polypeptide, Gastric H+/K+ ATPase Alpha, Gastric H+/K+ ATPase α, Hka, H+,K+-ATPase, H+/K+ ATPASE, Hkatpc |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- metal ion binding
- heavy metal translocating P-type ATPase
- protein binding
- magnesium ion binding
- plasma-membrane proton-efflux P-type ATPase
- E1-E2 ATPase
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- H+/K+-exchanging ATPase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Cation transporting ATPase, C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsing-remitting multiple sclerosis
- gastroesophageal reflux
- ulcerative gastroesophageal reflux
- erosive esophagitis
- Helicobacter pylori infection
- obstructive lung disease
- endocrine adenoma
- dyspepsia
- nonulcer dyspepsia
- gastrointestinal disturbance
role in cell
- morphology
- abnormal morphology
- quantity
- osmotic fragility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- apical membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- potassium ion transmembrane transport
- ion transmembrane transport
- establishment or maintenance of transmembrane electrochemical gradient
- cellular sodium ion homeostasis
- pH reduction
- response to xenobiotic stimulus
- regulation of proton transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- hydrogen:potassium-exchanging ATPase complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- potassium ion binding
- sodium:potassium-exchanging ATPase activity
- hydrogen:potassium-exchanging ATPase activity