HTR3E Gene Summary [Human]
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | HTR3E |
| Official Name | 5-hydroxytryptamine receptor 3E [Source:HGNC Symbol;Acc:HGNC:24005] |
| Ensembl ID | ENSG00000186038 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 3E |
| Synonyms | 5-HT3c1, 5-HT3-E, 5-hydroxytryptamine receptor 3E, LOC285241 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR3E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LGIC_ECD
- neurotransmitter receptor
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- protein binding
- extracellular ligand-gated ion channel
- Cation transporter family protein
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the HTR3E gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NPW
- D-tubocurarine
- ondansetron
- ergotamine
- palonosetron
- granisetron
- alosetron
- fenfluramine
- cisapride
- dolasetron
disease
- cognitive impairment
- schizophrenia
- inflammatory bowel disease
- migraines
- obesity
- diarrhea
- cancer
- vomiting
- chemotherapy sickness
- severe myoclonic epilepsy in infancy
regulated by
- RIC3
- D-tubocurarine
- ergotamine
- alosetron
- ondansetron
- fenfluramine
- granisetron
- dolasetron
- cisapride
- palonosetron
regulates
- Ca2+
- inorganic cation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR3E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- ion transmembrane transport
- synaptic transmission
- serotonin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- excitatory extracellular ligand-gated ion channel activity
- serotonin-gated cation channel activity