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Serotonin Receptor Signaling

Serotonin is a monoamine neurotransmitter synthesized in the CNS. It is an important modulator of sleep, body temperature and metabolism. Guanosine triphosphate cyclohydrolase I (GCH1) catalyzes the production of Tetrahydrobiopterin (BH4), a required cofactor in the conversion of L-tryptophan to 5-hydroxytryptophan which is then converted to serotonin. Serotonin is released at the synapse of the presynaptic neuron where it binds to its receptor on the postsynaptic neuron....

Serotonin Receptor Signaling

Pathway Summary

Serotonin is a monoamine neurotransmitter synthesized in the CNS. It is an important modulator of sleep, body temperature and metabolism. Guanosine triphosphate cyclohydrolase I (GCH1) catalyzes the production of Tetrahydrobiopterin (BH4), a required cofactor in the conversion of L-tryptophan to 5-hydroxytryptophan which is then converted to serotonin. Serotonin is released at the synapse of the presynaptic neuron where it binds to its receptor on the postsynaptic neuron.The 5-hydroxytryptamine (HT) receptors are serotonin receptors. All members of this family are GPCRs with the exception of 5-HT3 receptor which is a ligand gated ion channel. Serotonin acts via its receptor mainly to activate or inhibit adenylate cyclase thereby regulating vasoconstriction, opening/closing of channels and platelet aggregation.Serotonin is targeted for inactivation via its transporter SERT. Monoamine oxidase catalyzes the oxidative deamination of serotonin (5-HT) to 5-hydroxyindoleacetic acid which is translocated to cerebrospinal fluid.

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