SLC36A2 Gene Summary [Human]
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | SLC36A2 |
| Official Name | solute carrier family 36 member 2 [Source:HGNC Symbol;Acc:HGNC:18762] |
| Ensembl ID | ENSG00000186335 |
| Bio databases IDs | |
| Aliases | solute carrier family 36 member 2 |
| Synonyms | A530067G19Rik, LOC100503838, PAT2, solute carrier family 36 member 2, solute carrier family 36 (proton/amino acid symporter), member 2, TRAMD1, Tramdorin1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC36A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline transporter
- alanine transporter
- hydrogen:amino acid symporter
- glycine transporter
- hydrogen:proline symporter
- Solute carrier families 5 and 6-like; solute binding domain
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- endoplasmic reticulum membrane
- endosomal membrane
- paranodes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC36A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- L-alanine transport
- glycine transport
- proline transport
- amino acid transport
- proline transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- recycling endosome membrane
- vacuolar membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hydrogen:amino acid symporter activity
- glycine transmembrane transporter activity
- hydrogen:proline symporter activity
- amino acid transmembrane transporter activity
- L-proline transmembrane transporter activity
- L-alanine transmembrane transporter activity