Slc36a2 Gene Summary [Mouse]
Enables amino acid transmembrane transporter activity. Acts upstream of or within neutral amino acid transport and proton transmembrane transport. Located in endoplasmic reticulum membrane; plasma membrane; and recycling endosome membrane. Is expressed in several structures, including ear; face; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC36A2 (solute carrier family 36 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc36a2 |
| Official Name | solute carrier family 36 (proton/amino acid symporter), member 2 [Source:MGI Symbol;Acc:MGI:1891430] |
| Ensembl ID | ENSMUSG00000020264 |
| Bio databases IDs | |
| Aliases | solute carrier family 36 (proton/amino acid symporter), member 2 |
| Synonyms | A530067G19Rik, LOC100503838, PAT2, solute carrier family 36 member 2, solute carrier family 36 (proton/amino acid symporter), member 2, TRAMD1, Tramdorin1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc36a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline transporter
- alanine transporter
- hydrogen:amino acid symporter
- glycine transporter
- hydrogen:proline symporter
- Solute carrier families 5 and 6-like; solute binding domain
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- glycine
- alanine
- PCNA
- D-alanine
- L-proline
disease
- iminoglycinuria
- ischemic stroke
- hyperglycinuria
- diabetic nephropathy
- cannabis dependence
- acute myeloid leukemia
regulates
- D-proline
- H+
- D-alanine
- amino acids
- L-serine
- glycine
- beta-alanine
- L-proline
- GABA
- alanine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- endoplasmic reticulum membrane
- endosomal membrane
- paranodes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc36a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- L-alanine transport
- glycine transport
- proline transport
- amino acid transport
- proline transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- recycling endosome membrane
- vacuolar membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hydrogen:amino acid symporter activity
- glycine transmembrane transporter activity
- hydrogen:proline symporter activity
- amino acid transmembrane transporter activity
- L-proline transmembrane transporter activity
- L-alanine transmembrane transporter activity