NRIP1 Gene Summary [Human]
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NRIP1 |
| Official Name | nuclear receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8001] |
| Ensembl ID | ENSG00000180530 |
| Bio databases IDs | |
| Aliases | nuclear receptor interacting protein 1, receptor interacting protein 140, nuclear factor RIP140 |
| Synonyms | 6030458L20Rik, 8430438I05RIK, 9630050P12, CAKUT3, NUCLEAR FACTOR receptor INTERACTING protein 140, nuclear receptor interacting protein 1, RIP140 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NRIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nuclear receptor-interacting protein 1 repression 3
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- nuclear receptor domain
- transcription co-activator
- Sumoylation motif
- nucleic acid binding
- retinoic acid receptor binding
- Nuclear receptor-interacting protein 1 repression 1
- transcription co-repressor
- histone deacetylase binding
- estrogen receptor binding
- protein binding
- receptor binding
- sequence-specific DNA binding
- Nuclear receptor-interacting protein 1 repression 2
- Nuclear receptor-interacting protein 1 repression 4
- transcription repression domain
- double-stranded DNA binding
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the NRIP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- adenoma formation
- epithelial cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- hepatic steatosis
- gastric epithelial cancer
- obesity
- congenital anomalies of kidney and urinary tract
role in cell
- apoptosis
- proliferation
- expression in
- cell viability
- phosphorylation in
- migration
- cell proliferation
- colony formation ability
- survival
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intranuclear region
- cytosol
- nuclear foci
- MAD bodies
- nucleoplasm
- nucleoli
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NRIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- ovarian follicle rupture
- cellular response to estradiol stimulus
- lipid storage
- circadian regulation of gene expression
- circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- histone deacetylase complex
- cytosol
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- transcription coactivator activity
- histone deacetylase binding
- transcription corepressor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- estrogen receptor binding
- receptor binding
- retinoid X receptor binding
- glucocorticoid receptor binding