ATG5
ATG5 Gene Summary
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | ATG5 |
| Official Name | autophagy related 5 [Source:HGNC Symbol;Acc:HGNC:589] |
| Ensembl ID | ENSG00000057663 |
| Bio databases IDs | |
| Aliases | autophagy related 5 |
| Synonyms | 2010107M05Rik,3110067M24Rik,APG5,APG5L,APG5-LIKE,APOPTOSIS SPECIFIC,ASP,Atg5l,autophagy related 5,hAPG5,PADDY,POT1,SCAR25 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein Apg5
- APG8 conjugating enzyme
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the ATG5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CDK9
- ATG12
- SH3PXD2B
- MAVS
- OPTN
- TOP3B
- TECPR1
- ACTBL2
- AP2B1
- ZC3HAV1
disease
- asthma
- neoplasia
- osteoarthritis
- cancer
- natural killer cell neoplasm
- natural killer cell neoplasia
- organismal death
- systemic lupus erythematosus
- experimentally induced pancreatitis
- insomnia
regulated by
- dexamethasone
- lipopolysaccharide
- KRAS
- nutlin
- MTOR
- APP
- homocysteine thiolactone
- adenosine triphosphate
- calpain
- celecoxib
regulates
- UCP1
- NOS2
- TNF
- CDH1
- CDH2
- VIM
- AKT1
- IL10
- AKT
- IL6
role in cell
- cell death
- number
- proliferation
- apoptosis
- expression in
- invasion by
- migration
- signaling in
- accumulation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- autophagosomal membrane
- cellular membrane
- Plasma Membrane
- Mitochondria
- axonemes
- granules
- cytosol
- synapse
- autophagic vacuoles
- axons
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ATG5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- heart contraction
- response to iron(II) ion
- vasodilation
- response to xenobiotic stimulus
- chromatin organization
- negative regulation of innate immune response
- post-translational protein modification
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- cardiac muscle cell apoptotic process
- otolith development
- autophagy
- antigen processing and presentation of endogenous antigen
- regulation of cytokine production involved in immune response
- establishment of localization in cell
- negative regulation of protein ubiquitination
- aggrephagy
- macroautophagy
- negative regulation of reactive oxygen species metabolic process
- negative regulation of type I interferon production
- response to fungus
- macromitophagy
- mitochondrion degradation
- cellular response to nitrogen starvation
- regulation of release of sequestered calcium ion into cytosol
- blood vessel remodeling
- mucus secretion
- ventricular cardiac muscle cell development
- cellular response to nitrosative stress
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of mucus secretion
- negative thymic T cell selection
- negative regulation of defense response to virus
- protein ubiquitination
- negative regulation of phagocytosis
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- pre-autophagosomal structure membrane
- membrane
- Atg12-Atg5-Atg16 complex
- phagocytic vesicle membrane
- ER-mitochondrion membrane contact site
- cytosol
- macromolecular complex
- autophagic vacuole
- axon
- axoneme
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- Atg8 ligase activity