ZACN Gene Summary [Human]
LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | ZACN |
| Official Name | zinc activated ion channel [Source:HGNC Symbol;Acc:HGNC:29504] |
| Ensembl ID | ENSG00000186919 |
| Bio databases IDs | |
| Aliases | zinc activated ion channel |
| Synonyms | L2, LGICZ, LGICZ1, ZAC, ZAC1, zinc activated ion channel |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZACN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LGIC_ECD
- zinc ion binding
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- ligand-gated ion channel
- Cation transporter family protein
- ion channel
- cation channel
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZACN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to zinc ion
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- transmembrane signaling receptor activity
- ligand-gated ion channel activity
- extracellular ligand-gated ion channel activity