CCHCR1 Gene Summary [Human]
This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | CCHCR1 |
| Official Name | coiled-coil alpha-helical rod protein 1 [Source:HGNC Symbol;Acc:HGNC:13930] |
| Ensembl ID | ENSG00000204536 |
| Bio databases IDs | |
| Aliases | coiled-coil alpha-helical rod protein 1 |
| Synonyms | C6orf18, coiled-coil alpha-helical rod protein 1, coiled-coil α-helical rod protein 1, HCR, pg8, SBP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCHCR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha helical coiled-coil rod protein (HCR)
- RIM-binding protein of the cytomatrix active zone
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- identical protein binding
- Protein of unknown function (DUF745)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- cancer
- non-insulin-dependent diabetes mellitus
- psoriasis
- hypothyroidism
- Takayasu arteritis
- prostatic carcinoma
- prostate cancer
- head and neck squamous cell carcinoma
regulated by
role in cell
- expression in
- phosphorylation in
- proliferation
- apoptosis
- morphology
- size
- organization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- centriole
- midbody
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCHCR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- centriole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding