COG6 Gene Summary [Human]

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

Details

Type
Protein Coding
Official Symbol
COG6
Official Name
component of oligomeric golgi complex 6 [Source:HGNC Symbol;Acc:HGNC:18621]
Ensembl ID
ENSG00000133103
Bio databases IDs NCBI: 57511 Ensembl: ENSG00000133103
Aliases component of oligomeric golgi complex 6
Synonyms 4933405E16Rik, CDG2L, COD2, component of oligomeric golgi complex 6, mKIAA1134, SHNS
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COG6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Conserved oligomeric complex COG6
  • protein binding
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • asthma
  • rheumatoid arthritis
  • congenital disorder of glycosylation type 2L
  • psoriasis
  • multiple sclerosis
  • hereditary disorder
  • systemic lupus erythematosus
  • uterine leiomyoma
  • leiomyomatosis
regulated by
regulates
role in cell
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Golgi Apparatus
  • Golgi membrane
  • trans Golgi network

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human COG6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • glycosylation
  • Golgi organization
  • protein transport
  • intra-Golgi vesicle-mediated transport
  • retrograde transport, vesicle recycling within Golgi

Cellular Component

Where in the cell the gene product is active
  • Golgi transport complex
  • Golgi membrane
  • trans-Golgi network membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.