Cchcr1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within protein export from nucleus. Located in cytoplasm. Is expressed in brain ventricular layer; inferior colliculus; and pancreas epithelium. Used to study alopecia areata. Orthologous to human CCHCR1 (coiled-coil alpha-helical rod protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cchcr1 |
| Official Name | coiled-coil alpha-helical rod protein 1 [Source:MGI Symbol;Acc:MGI:2385321] |
| Ensembl ID | ENSMUSG00000040312 |
| Bio databases IDs | |
| Aliases | coiled-coil alpha-helical rod protein 1 |
| Synonyms | C6orf18, coiled-coil alpha-helical rod protein 1, coiled-coil α-helical rod protein 1, HCR, pg8, SBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cchcr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha helical coiled-coil rod protein (HCR)
- RIM-binding protein of the cytomatrix active zone
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- identical protein binding
- Protein of unknown function (DUF745)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- cancer
- non-insulin-dependent diabetes mellitus
- psoriasis
- hypothyroidism
- Takayasu arteritis
- prostatic carcinoma
- prostate cancer
- head and neck squamous cell carcinoma
regulated by
role in cell
- expression in
- phosphorylation in
- proliferation
- apoptosis
- morphology
- size
- organization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- centriole
- midbody
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cchcr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- centriole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding