SERPINB10 Gene Summary [Human]
This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB10 |
| Official Name | serpin family B member 10 [Source:HGNC Symbol;Acc:HGNC:8942] |
| Ensembl ID | ENSG00000242550 |
| Bio databases IDs | |
| Aliases | serpin family B member 10, protease inhibitor 10 (ovalbumin type), bomapin |
| Synonyms | 9830131G07, PI-10, serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10, Serpinb10-ps, serpin family B member 10, Trespin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINB10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- protease inhibitor
- serine protease inhibitor activity
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- secretory granule membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINB10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular space
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity