SRPK1 Gene Summary [Human]
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | SRPK1 |
| Official Name | SRSF protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:11305] |
| Ensembl ID | ENSG00000096063 |
| Bio databases IDs | |
| Aliases | SRSF protein kinase 1, SR protein kinase 1, serine/arginine-rich splicing factor kinase 1 |
| Synonyms | AU017960, Serine/arginine protein-specific kinase 1, serine/arginine-rich protein specific kinase 1, SFRSK1, SR Protein Kinase 1, SRSF protein kinase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRPK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- ATP binding
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- organismal death
- colon carcinoma
- colon epithelial cancer
- colorectal adenoma
- colorectal adenoma formation
- neoplastic cell transformation
- overall survival
- colorectal carcinoma
role in cell
- expression in
- apoptosis
- activation in
- phosphorylation in
- binding in
- cell death
- proliferation
- replication in
- condensation
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polyribosome fractions
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRPK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- chromosome segregation
- sperm chromatin condensation
- protein phosphorylation
- spliceosomal complex assembly
- regulation of mRNA processing
- innate immune response
- regulation of nuclear mRNA splicing, via spliceosome
- positive regulation of viral genome replication
- peptidyl-serine phosphorylation
- negative regulation of viral genome replication
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- nuclear matrix
- cytosol
- endoplasmic reticulum
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- RNA binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity