SRF Gene Summary [Human]
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | SRF |
| Official Name | serum response factor [Source:HGNC Symbol;Acc:HGNC:11291] |
| Ensembl ID | ENSG00000112658 |
| Bio databases IDs | |
| Aliases | serum response factor, minichromosome maintenance 1 homolog (S. cerevisiae), c-fos serum response element-binding transcription factor |
| Synonyms | MCM1, PRTF, RGD1559787, serum response factor, Sfr |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- SRF-type transcription factor (DNA-binding and dimerization domain)
- DNA binding domain
- nucleic acid binding
- nuclear localization sequence
- transcription activation domain
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- MADS
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
Pathways
Biological processes and signaling networks where the SRF gene in human plays a role, providing insight into its function and relevance in health or disease.
- Cardiac Hypertrophy Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- EGF Signaling
- ERK/MAPK Signaling
- G-Protein Coupled Receptor Signaling
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-6 Signaling
- LPS-stimulated MAPK Signaling
- Opioid Signaling Pathway
- p38 MAPK Signaling
- PDGF Signaling
- PEDF Signaling
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- fibrosis
- hepatocellular carcinoma
- hyperactive behavior
- congenital heart disease
- bleeding
- hypotrophy
- soft tissue sarcoma cancer
- atherosclerosis
role in cell
- apoptosis
- migration
- expression in
- cell death
- activation in
- accumulation in
- proliferation
- binding in
- quantity
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- positive regulation of filopodium assembly
- transcription from RNA polymerase II promoter
- cell migration involved in sprouting angiogenesis
- positive regulation of transcription by glucose
- associative learning
- positive regulation of sequence-specific DNA binding transcription factor activity
- stress fiber assembly
- skin morphogenesis
- face development
- response to toxin
- response to hypoxia
- cellular response to glucose stimulus
- platelet formation
- heart looping
- cardiac myofibril assembly
- dorsal aorta morphogenesis
- mesoderm formation
- long term synaptic depression
- trophectodermal cell differentiation
- sarcomere organization
- negative regulation of beta-amyloid clearance
- positive regulation of axon extension
- positive thymic T cell selection
- response to hormone stimulus
- morphogenesis of an epithelial sheet
- long-term memory
- epithelial structure maintenance
- tight junction assembly
- negative regulation of cell migration
- response to cytokine stimulus
- muscle cell homeostasis
- positive regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of cell proliferation
- cellular senescence
- tangential migration from the subventricular zone to the olfactory bulb
- regulation of smooth muscle cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- heart trabecula formation
- establishment of skin barrier
- positive regulation of smooth muscle contraction
- lung morphogenesis
- thymus development
- heart development
- neuron migration
- cardiac vascular smooth muscle cell differentiation
- patterning of blood vessels
- megakaryocyte development
- platelet activation
- angiogenesis involved in wound healing
- cell-matrix adhesion
- lung smooth muscle development
- hemopoietic stem cell differentiation
- positive regulation of cell differentiation
- erythrocyte development
- hippocampus development
- neuron development
- bronchus cartilage development
- cardiac muscle cell myoblast differentiation
- filopodium assembly
- trachea cartilage development
- eyelid development in camera-type eye
- thyroid gland development
- axon extension
- regulation of cell adhesion
- actin cytoskeleton organization
- primitive streak formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- serum response element binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- primary miRNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity