LEFTY1
LEFTY1 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | LEFTY1 |
| Official Name | left-right determination factor 1 [Source:HGNC Symbol;Acc:HGNC:6552] |
| Ensembl ID | ENSG00000243709 |
| Bio databases IDs | |
| Aliases | left-right determination factor 1 |
| Synonyms | LEFTB,left-right determination factor 1,LEFTYB,RGD1561867 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- growth factor
Pathways
Biological processes and signaling networks where the LEFTY1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- POU5F1
- SMAD3
- MTOR
- LEFTY2
- miR-291a-3p (and other miRNAs w/seed AAGUGCU)
- GDF3
- WTAP
disease
- osteogenesis imperfecta type III
- infection by HIV-1
regulated by
- beta-estradiol
- TGFB1
- INHBA
- ACVR1B
- dexamethasone
- megakaryocytes
- mifepristone
- NR3C1
- RO-3306
- FOXA1
regulates
- reporter gene
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the LEFTY1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- anterior/posterior axis specification
- heart morphogenesis
- transforming growth factor beta receptor signaling pathway
- determination of left/right symmetry
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- transforming growth factor beta receptor binding
- cytokine activity