INHBA
INHBA Gene Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
Details
| Type | Processed Transcript |
| Official Symbol | INHBA |
| Official Name | inhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066] |
| Ensembl ID | ENSG00000122641 |
| Bio databases IDs | |
| Aliases | inhibin subunit beta A |
| Synonyms | Activin A,Activin beta A,Activin-β-a,Beta-A,beta A INHIBIN,EDF,FRP,Inhibin A,INHIBIN beta A,inhibin subunit beta A,inhibin subunit β A,INHIBIN β A,inhibin, β a,Inhibin β a subunit,β-A,β A INHIBIN |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- TGF_beta_SF
- Transforming growth factor beta like domain
- hormone
- protein binding
- receptor binding
- cytokine
- identical protein binding
- growth factor
- TGF-beta propeptide
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the INHBA gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- INHBC
- INHA
- ACVR1B
- RAC3
- FST
- AKT1
- activin receptor
- ACVR2B
- activin receptor type 2
- IGF2BP1
disease
- diabetes mellitus
- neoplasia
- epithelial neoplasia
- breast cancer
- weight gain
- schizophrenia
- colorectal adenoma
- colorectal adenoma formation
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
regulated by
- D-glucose
- insulin
- PMSG
- tetradecanoylphorbol acetate
- TNF
- tretinoin
- POU5F1
- MYC
- hydrocortisone
- CFI-402257
regulates
- JNK
- lipid
- CASP3
- CDKN1A
- ERK1/2
- IL6
- p38 MAPK
- IFNG
- CCR2
- PCNA
role in cell
- cell death
- apoptosis
- quantity
- proliferation
- expression in
- phosphorylation in
- expansion
- activation
- stimulation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the INHBA gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- male gonad development
- transcription from RNA polymerase II promoter
- positive regulation of erythrocyte differentiation
- hemopoietic progenitor cell differentiation
- cellular response to follicle-stimulating hormone stimulus
- activin receptor signaling pathway
- positive regulation of protein metabolic process
- positive regulation of collagen biosynthetic process
- negative regulation of macrophage differentiation
- hair follicle development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- autophagy
- cellular response to hypoxia
- negative regulation of interferon-gamma production
- progesterone secretion
- SMAD protein signal transduction
- cell-cell signaling
- negative regulation of B cell differentiation
- hemoglobin biosynthetic process
- positive regulation of ovulation
- erythrocyte differentiation
- positive regulation of gene expression
- mesodermal cell differentiation
- endodermal cell differentiation
- negative regulation of cell proliferation
- palate development
- response to wounding
- extrinsic apoptotic signaling pathway
- nervous system development
- odontogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- striatal medium spiny neuron differentiation
- negative regulation of follicle-stimulating hormone secretion
- regulation of follicle-stimulating hormone secretion
- cytokine-mediated signaling pathway
- cellular response to cholesterol
- positive regulation of follicle-stimulating hormone secretion
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of SMAD protein import into nucleus
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- cell surface receptor signaling pathway
- defense response
- eyelid development in camera-type eye
- negative regulation of phosphorylation
- regulation of transcription from RNA polymerase II promoter
- ovarian follicle development
- GABAergic neuron differentiation
- cardiac fibroblast cell development
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cell differentiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- activin A complex
- inhibin A complex
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- growth factor activity
- protein binding
- type II activin receptor binding
- peptide hormone binding
- cytokine activity
- hormone activity