Slc26a3 Gene Summary [Mouse]
This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | Slc26a3 |
| Official Name | solute carrier family 26, member 3 [Source:MGI Symbol;Acc:MGI:107181] |
| Ensembl ID | ENSMUSG00000001225 |
| Bio databases IDs | |
| Aliases | solute carrier family 26, member 3 |
| Synonyms | 9030623B18Rik, 9130013M11Rik, CLD, DRA, solute carrier family 26 member 3, solute carrier family 26, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc26a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sulfate permease family
- PRK11660
- antiporter
- high affinity sulphate transporter 1
- protein binding
- PDZ binding motif
- chloride transporter
- inorganic anion exchanger
- bicarbonate transporter
- sulphate transporter and anti-sigma factor antagonist domain
- transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- congenital secretory diarrhea, chloride type
- androgenic alopecia
- organismal death
- colorectal cancer
- polycystic kidney disease
- Huntington disease
- intestinal cancer
- cholelithiasis
regulates
- IKB
- blood urea nitrogen
- RELA
- chloride
- ion
- iodine
- Na+
- aldosterone
- K+
- anion
role in cell
- proliferation
- growth
- cytostasis
- response by
- hyperpolarization
- capacitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- apical cell surfaces
- apical membrane
- sperm midpiece
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc26a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- sperm capacitation
- intracellular pH elevation
- cellular response to cAMP
- membrane hyperpolarization
- oxalate transport
- anion transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- sperm midpiece
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- secondary active sulfate transmembrane transporter activity
- protein binding
- oxalate transmembrane transporter activity
- inorganic anion exchanger activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- sulfate transmembrane transporter activity