Slc26a6 Gene Summary [Mouse]
Enables several functions, including PDZ domain binding activity; organic anion transmembrane transporter activity; and sulfate transmembrane transporter activity. Involved in several processes, including bicarbonate transport; carboxylic acid transport; and cellular response to cAMP. Acts upstream of or within establishment of localization in cell. Located in several cellular components, including apical plasma membrane; brush border membrane; and sperm midpiece. Orthologous to human SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Slc26a6 |
| Official Name | solute carrier family 26, member 6 [Source:MGI Symbol;Acc:MGI:2159728] |
| Ensembl ID | ENSMUSG00000023259 |
| Bio databases IDs | |
| Aliases | solute carrier family 26, member 6 |
| Synonyms | AC168054.2, B930010B04Rik, CFEX, Pat-1, solute carrier family 26 member 6, solute carrier family 26, member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc26a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- formate transporter
- oxalate transporter
- Sulfate permease family
- efflux permease
- sulfate transporter
- high affinity sulphate transporter 1
- protein binding
- chloride transporter
- identical protein binding
- bicarbonate transporter
- sulphate transporter and anti-sigma factor antagonist domain
- PDZ-domain binding
- anion transporter
- sulfate:bicarbonate antiporter
- PRK11660
- antiporter
- PDZ binding motif
- inorganic anion exchanger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- urolithiasis
regulates
- bicarbonate
- oxalic acid
- dipeptide
- chloride
- ion
- SLC13A2
- formic acid
- sulfate
role in cell
- response by
- capacitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- vesicles
- cytosol
- vesicle membrane
- apical membrane
- basolateral membrane
- sperm midpiece
- microsomal membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc26a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfate transport
- mannitol transport
- positive regulation of dipeptide transmembrane transport
- epithelial fluid transport
- chloride transport
- oxalic acid secretion
- regulation of intracellular pH
- ion transport
- intestinal absorption
- sperm capacitation
- intracellular pH elevation
- cellular response to fructose stimulus
- cellular response to cAMP
- transepithelial transport
- transepithelial chloride transport
- establishment of localization in cell
- oxalate transport
- cellular response to interferon-gamma
- formate transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- chloride channel complex
- cytoplasmic vesicle membrane
- brush border membrane
- sperm midpiece
- vesicle membrane
- membrane
- cytosol
- vesicle
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- formate transmembrane transporter activity
- secondary active sulfate transmembrane transporter activity
- efflux transmembrane transporter activity
- oxalate transmembrane transporter activity
- PDZ domain binding
- inorganic anion exchanger activity
- chloride channel activity
- chloride transmembrane transporter activity
- transferase activity
- bicarbonate transmembrane transporter activity
- sulfate transmembrane transporter activity