Gabrg1 Gene Summary [Mouse]
Predicted to enable GABA receptor binding activity and GABA-gated chloride ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Acts upstream of or within chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in central nervous system and eye. Used to study trigeminal neuralgia. Orthologous to human GABRG1 (gamma-aminobutyric acid type A receptor subunit gamma1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrg1 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 [Source:MGI Symbol;Acc:MGI:103156] |
| Ensembl ID | ENSMUSG00000001260 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 |
| Synonyms | GabaA, GabaA/BZ, gamma-aminobutyric acid type A receptor subunit gamma 1, γ-aminobutyric acid type A receptor subunit gamma1, γ-aminobutyric acid type A receptor subunit γ 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- Neurotransmitter-gated ion-channel ligand binding domain
- protein binding
- receptor binding
- Cation transporter family protein
- ion channel
Pathways
Biological processes and signaling networks where the Gabrg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- muscimol
- clorazepate
- oxazepam
- midazolam
- chlordiazepoxide
- nitrazepam
- triazolam
- quazepam
- felbamate
- tracazolate
disease
- infection
- chronic obstructive pulmonary disease
- stroke
- acute coronary syndrome
- rheumatoid arthritis
- arthritis
- cancer
- plasma cell myeloma
- myositis
- gastrointestinal stromal tumor
role in cell
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite membrane
- postsynaptic membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GABA-A receptor activity
- chloride channel activity
- GABA receptor binding
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity