Idh3g Gene Summary [Mouse]
Predicted to enable isocitrate dehydrogenase (NAD+) activity and magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Idh3g |
| Official Name | isocitrate dehydrogenase 3 (NAD+), gamma [Source:MGI Symbol;Acc:MGI:1099463] |
| Ensembl ID | ENSMUSG00000002010 |
| Bio databases IDs | |
| Aliases | isocitrate dehydrogenase 3 (NAD+), gamma |
| Synonyms | H-IDHG, IDH, Idh γ, isocitrate dehydrogenase 3 (NAD+), gamma, isocitrate dehydrogenase 3 (NAD+), γ, Isocitrate dehydrogenase 3 γ, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Idh3g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Isocitrate/isopropylmalate dehydrogenase
- isocitrate dehydrogenase (NAD)
- enzyme
- protein binding
- enzyme activator activity
- magnesium ion binding
Pathways
Biological processes and signaling networks where the Idh3g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Idh3g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- isocitrate metabolic process
- tricarboxylic acid cycle
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- nucleolus
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- isocitrate dehydrogenase (NAD+) activity
- protein binding
- NAD binding