Kpna6 Gene Summary [Mouse]
Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in cytosol. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kpna6 |
| Official Name | karyopherin (importin) alpha 6 [Source:MGI Symbol;Acc:MGI:1100836] |
| Ensembl ID | ENSMUSG00000003731 |
| Bio databases IDs | |
| Aliases | karyopherin (importin) alpha 6 |
| Synonyms | IMPORTIN alpha 7, IMPORTIN α 7, IPOA7, KARYOPHERIN alpha 6, karyopherin subunit alpha 6, karyopherin subunit α 6, KARYOPHERIN α 6, Kpna5, LOC100363922, NPI-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kpna6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Atypical Arm repeat
- HEAT-like repeat
- importin beta binding domain
- Armadillo/beta-catenin-like repeats
- protein binding
- HEAT repeats
Pathways
Biological processes and signaling networks where the Kpna6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- stuttering
- oligozoospermia
- NPM1 mutation positive acute myeloid leukemia
- hypoplasia
- growth failure
role in cell
- apoptosis
- formation
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kpna6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maternal process involved in female pregnancy
- protein import into nucleus
- NLS-bearing substrate import into nucleus
- transcription from RNA polymerase II promoter
- viral genome replication
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cytokine production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- NLS-dependent protein nuclear import complex
- host cell
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- nuclear localization sequence binding