Xpa Gene Summary [Mouse]
Predicted to enable DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; nucleotide-excision repair; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Is expressed in forelimb bud. Used to study xeroderma pigmentosum group A. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xpa |
| Official Name | xeroderma pigmentosum, complementation group A [Source:MGI Symbol;Acc:MGI:99135] |
| Ensembl ID | ENSMUSG00000028329 |
| Bio databases IDs | |
| Aliases | xeroderma pigmentosum, complementation group A |
| Synonyms | AI573865, xeroderma pigmentosum, complementation group A, Xeroderma pigmentosum group a correcting, XP1, XPAC, XPA, DNA damage recognition and repair factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DBD_XPA-like
- XPA protein N-terminal
- DNA binding domain
- nuclear localization sequence
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- damaged DNA binding
- double-stranded DNA binding
- replication protein A binding domain
- protein homodimerization
- XPA protein C-terminus
- DNA repair protein
Pathways
Biological processes and signaling networks where the Xpa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- benign neoplasia
- papillomatosis
- neurological disorder
- xeroderma pigmentosum complementation group A
role in cell
- cell viability
- proliferation
- function
- cell death
- apoptosis
- number
- survival
- quantity
- growth
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic bridges
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- UV-damage excision repair
- base-excision repair
- UV protection
- nucleotide-excision repair, DNA damage recognition
- response to auditory stimulus
- nucleotide-excision repair
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleotide-excision repair factor 1 complex
- nucleus
- intercellular bridge
- DNA replication factor A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- protein homodimerization activity
- metal ion binding
- damaged DNA binding