Phox2a Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in oculomotor nerve formation and trochlear nerve formation. Acts upstream of or within nervous system development; regulation of respiratory gaseous exchange; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; epibranchial placode; genitourinary system; and nervous system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 2. Orthologous to human PHOX2A (paired like homeobox 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phox2a |
| Official Name | paired-like homeobox 2a [Source:MGI Symbol;Acc:MGI:106633] |
| Ensembl ID | ENSMUSG00000007946 |
| Bio databases IDs | |
| Aliases | paired-like homeobox 2a |
| Synonyms | ARIX, CFEOM2, FEOM2, NCAM2, paired like homeobox 2A, Phox2, Pmx2, PMX2A, Px2a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phox2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital fibrosis of extraocular muscle type 2
- MYCN amplification positive aggressive neuroblastoma
- neuroblastoma formation
- neuroblastoma
- MYCN amplification negative neuroblastoma
role in cell
- apoptosis
- differentiation
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phox2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- noradrenergic neuron differentiation
- sympathetic nervous system development
- midbrain development
- dopaminergic neuron differentiation
- locus ceruleus development
- somatic motor neuron differentiation
- regulation of respiratory gaseous exchange
- oculomotor nerve formation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- trochlear nerve formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity