Kif1b Gene Summary [Mouse]
Enables plus-end-directed microtubule motor activity. Involved in chemical synaptic transmission and organelle transport along microtubule. Located in mitochondrion. Is active in postsynapse and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skeletal musculature. Used to study Charcot-Marie-Tooth disease type 2A1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; hepatocellular carcinoma; multiple sclerosis; neuroblastoma; and ovary epithelial cancer. Orthologous to human KIF1B (kinesin family member 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif1b |
| Official Name | kinesin family member 1B [Source:MGI Symbol;Acc:MGI:108426] |
| Ensembl ID | ENSMUSG00000063077 |
| Bio databases IDs | |
| Aliases | kinesin family member 1B |
| Synonyms | A530096N05Rik, CMT2, CMT2A, CMT2A1, D4Mil1e, HMSNII, KIF1Bp130, KIF1Bp204, Kinesin-1B, kinesin family member 1B, Kip1p, KLP, NBLST1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin protein 1B
- Myosin and Kinesin motor domain
- Forkhead associated domain
- Pleckstrin homology-like domain
- protein binding
- ATPase
- microtubule motor protein
- kinesin binding
- Kinesin-associated
- forkhead associated (FHA) domain superfamily
- Kinesin motor, catalytic domain
- microtubule binding
- Kinesin protein
- kinase binding
- FHA domain
- Kinesin motor domain
- PH domain
- tail domain
- plus-end-directed kinesin ATPase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- hepatocellular carcinoma
- epithelial cancer
- multiple sclerosis
- Parkinson disease
- susceptibility to neuroblastoma
- hemangioma
- angiomatosis
- Charcot-Marie-Tooth disease type 2A1
phenotypes
- abnormal embryo size
- abnormal facial morphology
- abnormal head shape
- abnormal limb morphology
- abnormal outer ear morphology
- decreased blood urea nitrogen level
- decreased circulating glucose level
- hyperactivity
- increased body length
- increased circulating chloride level
- increased circulating sodium level
- increased hemoglobin content
- increased mean corpuscular hemoglobin concentration
- preweaning lethality complete penetrance
- respiratory system phenotype
- abnormal axonal transport
- abnormal blood urea nitrogen level
- abnormal brain commissure morphology
- abnormal brainstem morphology
- abnormal circulating glucose level
- abnormal circulating sodium level
- abnormal hemoglobin content
- abnormal hippocampus morphology
- abnormal locomotor activation
- abnormal locomotor behavior
- abnormal motor coordination/ balance
- abnormal spinal cord ventral horn morphology
- abnormal synaptic vesicle number
- decreased brain size
- decreased neuron number
- embryonic lethality
- impaired coordination
- lordosis
- neonatal lethality complete penetrance
- progressive muscle weakness
- respiratory failure
- unresponsive to tactile stimuli
role in cell
- apoptosis
- expression in
- differentiation
- transport in
- accumulation in
- survival
- outgrowth
- quantity
- number
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- presynaptic regions
- postsynaptic region
- Mitochondria
- synaptic vesicles
- neurites
- cytoplasmic vesicles
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
- vesicle-mediated transport
- cytoskeleton-dependent intracellular transport
- neuromuscular synaptic transmission
- apoptotic process
- microtubule-based movement
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- dendrite
- mitochondrion
- cytoplasmic vesicle
- kinesin complex
- synaptic vesicle membrane
- neuron projection
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- kinesin binding
- plus-end-directed microtubule motor activity
- microtubule binding