Htra2 Gene Summary [Mouse]
Enables peptidase activity. Involved in several processes, including cellular response to oxidative stress; negative regulation of type 2 mitophagy; and positive regulation of apoptotic process. Acts upstream of or within several processes, including adult walking behavior; intrinsic apoptotic signaling pathway; and nervous system development. Located in cytoplasmic side of plasma membrane and mitochondrion. Part of CD40 receptor complex. Is expressed in several structures, including gut; nervous system; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htra2 |
| Official Name | HtrA serine peptidase 2 [Source:MGI Symbol;Acc:MGI:1928676] |
| Ensembl ID | ENSMUSG00000068329 |
| Bio databases IDs | |
| Aliases | HtrA serine peptidase 2 |
| Synonyms | HtrA serine peptidase 2, MGCA8, mnd2, OMI, PARK13, PRSS25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htra2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- Tryp_SPc
- catalytic domain
- peptidase
- enzyme inhibitor activity
- canonical PDZ domain
- enzyme
- enzyme regulator activity
- protein binding
- PDZ domain
- cleavage site
- identical protein binding
- IAP binding domain
- protein serine/threonine kinase inhibitor
- serine endopeptidase
- serine-type peptidase
- active site
- Trypsin-like peptidase domain
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Htra2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- 3-methylglutaconic aciduria type 8
- growth failure
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- ataxia
- Parkinson disease type 13
- akinesia
- muscle weakness
- lack of spontaneous movement
phenotypes
- abnormal action potential
- abnormal astrocyte morphology
- abnormal basal ganglion morphology
- abnormal behavior
- abnormal bone marrow cell morphology/development
- abnormal brain morphology
- abnormal cerebellar granule cell morphology
- abnormal gait
- abnormal immune system morphology
- abnormal interleukin level
- abnormal locomotor behavior
- abnormal mitochondrial crista morphology
- abnormal mitochondrial inner membrane morphology
- abnormal mitochondrion morphology
- abnormal nervous system morphology
- abnormal respiratory electron transport chain
- abnormal seminal vesicle morphology
- abnormal spinal cord morphology
- abnormal stationary movement
- abnormal thymus morphology
- abnormal tumor necrosis factor level
- akinesia
- ataxia
- bradykinesia
- decreased body size
- decreased body weight
- decreased brain size
- decreased brain weight
- decreased double-positive T cell number
- decreased grip strength
- decreased lymphocyte cell number
- decreased pre-B cell number
- decreased pro-B cell number
- decreased single-positive T cell number
- decreased total body fat amount
- dilated mitochondria
- dystonia
- dystrophic muscle
- gliosis
- hunched posture
- hypoactivity
- impaired balance
- impaired coordination
- increased apoptosis
- increased brain apoptosis
- increased stereotypic behavior
- increased susceptibility to neuronal excitotoxicity
- lethargy
- limb grasping
- loss of basal ganglia neurons
- motor neuron degeneration
- muscle spasm
- muscle weakness
- muscular atrophy
- neurodegeneration
- no spontaneous movement
- paralysis
- postnatal growth retardation
- premature death
- seizures
- small heart
- small spleen
- small thymus
- sparse hair
- spleen atrophy
- thymus atrophy
- tremors
role in cell
- number
- cell death
- expression in
- activation in
- loss
- apoptosis
- production in
- degradation in
- molecular cleavage in
- excitotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial fraction
- cytoskeleton
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- mitochondrial intermembrane space
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htra2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- negative regulation of cell cycle
- execution phase of apoptosis
- positive regulation of execution phase of apoptosis
- response to herbicide
- negative regulation of neuron apoptotic process
- adult walking behavior
- cellular response to heat
- forebrain development
- pentacyclic triterpenoid metabolic process
- intracellular signal transduction
- neuron apoptotic process
- cellular response to interferon-beta
- mitochondrial protein catabolic process
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- protein catabolic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- ceramide metabolic process
- neuron development
- mitochondrion organization
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to retinoic acid
- cellular response to growth factor stimulus
- positive regulation of apoptotic process
- proteolysis
- cellular response to oxidative stress
- protein autoprocessing
- programmed cell death
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- chromatin
- internal side of plasma membrane
- endoplasmic reticulum membrane
- nucleus
- mitochondrial intermembrane space
- mitochondrial membrane
- cytoskeleton
- mitochondrion
- membrane
- cytosol
- CD40 receptor complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity
- unfolded protein binding
- peptidase activity