Slc1a7 Gene Summary [Mouse]
Enables L-glutamate transmembrane transporter activity; extracellularly glutamate-gated chloride channel activity; and glutamate:sodium symporter activity. Involved in L-glutamate transmembrane transport and chloride transmembrane transport. Acts upstream of or within monoatomic anion transmembrane transport. Located in photoreceptor cell terminal bouton and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including cerebellum; mesenchyme of metanephros; and retina nuclear layer. Orthologous to human SLC1A7 (solute carrier family 1 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc1a7 |
| Official Name | solute carrier family 1 (glutamate transporter), member 7 [Source:MGI Symbol;Acc:MGI:2444087] |
| Ensembl ID | ENSMUSG00000008932 |
| Bio databases IDs | |
| Aliases | solute carrier family 1 (glutamate transporter), member 7 |
| Synonyms | A930031E15Rik, AAAT, EAAT5, solute carrier family 1 (glutamate transporter), member 7, solute carrier family 1 member 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc1a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:dicarboxylate symporter family
- glutamate transporter
- glutamate-gated chloride channel
- glutamate:sodium symporter
- TcyP
- high-affinity glutamate transporter
- transporter
- anion transporter
Pathways
Biological processes and signaling networks where the Slc1a7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- amyotrophic lateral sclerosis
- hippocampal atrophy
- major depression
- fatigue
- cerebellar ataxia
- multiple system atrophy
- fragile X syndrome
- social anxiety disorder
- Ullrich congenital muscular dystrophy
regulates
- chloride
- L-glutamic acid
- ion
- anion
- dicarboxylic acid
- neurotransmitter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc1a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dicarboxylic acid transport
- neurotransmitter transport
- ion transport
- regulation of excitatory postsynaptic membrane potential
- neurotransmitter uptake
- neutral amino acid transport
- L-glutamate transport
Cellular Component
Where in the cell the gene product is active
- synaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neutral amino acid transmembrane transporter activity
- extracellular-glutamate-gated chloride channel activity
- high-affinity glutamate transmembrane transporter activity
- glutamate:sodium symporter activity
- L-glutamate transmembrane transporter activity