Pcna Gene Summary [Mouse]
Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus; nuclear lamina; and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; genitourinary system; jaw; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcna |
| Official Name | proliferating cell nuclear antigen [Source:MGI Symbol;Acc:MGI:97503] |
| Ensembl ID | ENSMUSG00000027342 |
| Bio databases IDs | |
| Aliases | proliferating cell nuclear antigen |
| Synonyms | ATLD2, Pcna/cyclin, PCNAR, proliferating cell nuclear antigen |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcna often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Proliferating cell nuclear antigen, N-terminal domain
- enzyme binding
- central domain
- transcription factor binding
- chromatin binding
- enzyme
- estrogen receptor binding
- protein binding
- identical protein binding
- purine-specific mismatch base pair DNA N-glycosylase
- proliferating cell nuclear antigen (pcna)
- beta_clamp
- binding protein
- damaged DNA binding
- receptor tyrosine kinase binding
- double-stranded DNA binding
- interdomain connector loop
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the Pcna gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- neoplasia
- colorectal cancer
- rheumatoid arthritis
- Alzheimer disease
- Huntington disease
- organismal death
- Sjögren syndrome
- breast cancer
- Dent disease
role in cell
- cell death
- phosphorylation in
- apoptosis
- replication in
- proliferation
- survival
- degradation in
- quantity
- stabilization in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- detergent-insoluble fractions
- membrane fraction
- insoluble fractions
- nucleolar fraction
- Cytoplasm
- cell surface
- intracellular space
- centrosome
- lipid droplets
- cytoplasmic aggregates
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear lamina
- germinal vesicles
- DNA replication foci
- centromeres
- chromatin
- replication fork
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcna gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- positive regulation of deoxyribonuclease activity
- positive regulation of DNA-directed DNA polymerase activity
- leading strand elongation
- response to cadmium ion
- positive regulation of DNA replication
- base-excision repair, gap-filling
- mismatch repair
- epithelial cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- response to estradiol stimulus
- cellular response to UV
- replication fork processing
- cellular response to xenobiotic stimulus
- cellular response to hydrogen peroxide
- translesion synthesis
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- PCNA complex
- nuclear body
- cyclin-dependent protein kinase holoenzyme complex
- nuclear replication fork
- chromatin
- nuclear lamina
- nucleoplasm
- male germ cell nucleus
- replication fork
- nucleus
- chromosome, telomeric region
- centrosome
- extracellular vesicular exosome
- replisome
- PCNA-p21 complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- histone acetyltransferase binding
- purine-specific mismatch base pair DNA N-glycosylase activity
- chromatin binding
- damaged DNA binding
- DNA polymerase processivity factor activity
- MutLalpha complex binding
- DNA polymerase binding
- protein binding
- estrogen receptor binding
- dinucleotide insertion or deletion binding
- receptor tyrosine kinase binding
- enzyme binding