Prune1 Gene Summary [Mouse]
Predicted to enable exopolyphosphatase activity; phosphatase activity; and tubulin binding activity. Predicted to be involved in regulation of microtubule polymerization and regulation of neurogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including exocrine gland; eye; genitourinary system; gut; and nervous system. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prune1 |
| Official Name | prune exopolyphosphatase [Source:MGI Symbol;Acc:MGI:1925152] |
| Ensembl ID | ENSMUSG00000015711 |
| Bio databases IDs | |
| Aliases | prune exopolyphosphatase |
| Synonyms | 9230112O05Rik, C130058A12, DRES-17, H-PRUNE, HTCD37, NMIHBA, PRUNE, prune exopolyphosphatase, prune exopolyphosphatase 1, PRUNEM1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prune1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHHA2 domain
- DHH family
- tubulin binding
- phosphatase
- enzyme
- protein binding
- exopolyphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neurodevelopmental disorder with microcephaly, hypotonia and variable brain anomalies
- hereditary disorder
- gestational diabetes mellitus
- major depression
- PRUNE1-related disorder
regulates
- adenosine triphosphate
- focal adhesion kinase
- ATP synthase
- RAC
- PXN
- polyphosphate
- ATP5F1A
role in cell
- proliferation
- expression in
- motility
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- focal adhesions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prune1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule polymerization
- regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- inorganic diphosphatase activity
- protein binding
- metal ion binding
- exopolyphosphatase activity
- phosphatase activity