Abo Gene Summary [Mouse]
Enables fucosylgalactoside 3-alpha-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus; extracellular region; and vesicle. Is expressed in alimentary system; male reproductive gland or organ; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abo |
| Official Name | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Source:MGI Symbol;Acc:MGI:2135738] |
| Ensembl ID | ENSMUSG00000015787 |
| Bio databases IDs | |
| Aliases | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) |
| Synonyms | A3GALNT, A3GALT1, Abo2, ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase, ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase), ABO, α 1-3-N-acetylgalactosaminyltransferase and α 1-3-galactosyltransferase, GTB, NAGAT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycoprotein-fucosylgalactoside alpha-galactosyltransferase
- nucleotide binding
- UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase
- galactosyltransferase
- antigen binding
- enzyme
- manganese ion binding
- glycosyltransferase family A
- glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein glycosylation
- lipid glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- vesicle
- Golgi apparatus
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- antigen binding
- glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
- fucosylgalactoside 3-alpha-galactosyltransferase activity
- manganese ion binding