Ggnbp2 Gene Summary [Mouse]
Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of peptidyl-tyrosine phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and spleen. Orthologous to human GGNBP2 (gametogenetin binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ggnbp2 |
| Official Name | gametogenetin binding protein 2 [Source:MGI Symbol;Acc:MGI:2387356] |
| Ensembl ID | ENSMUSG00000020530 |
| Bio databases IDs | |
| Aliases | gametogenetin binding protein 2 |
| Synonyms | AI451896, C75939, D330017P12RIK, DIF-3, gametogenetin binding protein 2, LCRG1, LZK1, ZFP403, ZNF403 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ggnbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- azoospermia
- obesity
- organismal death
- dyslexia
- eczema
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
regulated by
- FBXO45
- Z-LLL-CHO
- camptothecin
- SLFN11
- prexasertib
regulates
- STAT
role in cell
- apoptosis
- differentiation
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ggnbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of peptidyl-serine phosphorylation of STAT protein
- negative regulation of gene expression
- labyrinthine layer blood vessel development
- negative regulation of cell proliferation
- spermatogenesis
- cell differentiation
- negative regulation of tyrosine phosphorylation of STAT protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic vesicle