Fbxw11 Gene Summary [Mouse]
Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of non-canonical NF-kappaB signal transduction; and protein modification process. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system and yolk sac. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxw11 |
| Official Name | F-box and WD-40 domain protein 11 [Source:MGI Symbol;Acc:MGI:2144023] |
| Ensembl ID | ENSMUSG00000020271 |
| Bio databases IDs | |
| Aliases | F-box and WD-40 domain protein 11 |
| Synonyms | 2310065A07Rik, Beta-TRCP2, BTRC2, BTRCP2, F-box and WD-40 domain protein 11, F-box and WD repeat domain containing 11, Fbw11, FBW1B, FBXW1B, HOS, NEDJED, β-TRCP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxw11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- D domain of beta-TrCP
- F-box domain
- WD40 repeats
- F-box domain superfamily
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- F-box-like
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- neurodevelopmental, jaw, eye, and digital syndrome
- Hutchinson-Gilford progeria syndrome
- infection by HIV-1
role in cell
- growth
- CSN5i-3 sensitivity
- transport in
- neddylation in
- ubiquitination in
- CB-5083 sensitivity
- degradation in
- K63 polyubiquitination in
- JG-231 resistance
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Nucleus
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxw11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- protein polyubiquitination
- nuclear migration
- protein dephosphorylation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- brain morphogenesis
- positive regulation of proteolysis
- positive regulation of circadian rhythm
- protein destabilization
- establishment of mitotic spindle orientation
- proteasomal ubiquitin-dependent protein catabolic process
- rhythmic process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- vesicle transport along microtubule
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- Wnt receptor signaling pathway
- microtubule organizing center organization
- retrograde axon cargo transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- centrosome
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
- cytoplasmic microtubule
- kinetochore
- neuronal cell body
- neuron projection
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule plus-end binding
- protein dimerization activity
- dynein complex binding