Tac4 Gene Summary [Mouse]
Enables receptor ligand activity; substance K receptor binding activity; and substance P receptor binding activity. Involved in positive regulation of cytosolic calcium ion concentration and tachykinin receptor signaling pathway. Acts upstream of or within positive regulation of saliva secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Orthologous to human TAC4 (tachykinin precursor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tac4 |
| Official Name | tachykinin 4 [Source:MGI Symbol;Acc:MGI:1931130] |
| Ensembl ID | ENSMUSG00000020872 |
| Bio databases IDs | |
| Aliases | tachykinin 4 |
| Synonyms | EK, HK, HK-1, PPT-C, tachykinin 4, tachykinin precursor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tac4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- receptor agonist activity
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tac4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- regulation of blood pressure
- tachykinin receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- substance P receptor binding