Ppp4r4 Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in cytoplasm. Predicted to be part of protein serine/threonine phosphatase complex. Predicted to be active in cytosol. Is expressed in early conceptus; secondary oocyte; and telencephalon mantle layer. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp4r4 |
| Official Name | protein phosphatase 4, regulatory subunit 4 [Source:MGI Symbol;Acc:MGI:1921771] |
| Ensembl ID | ENSMUSG00000021209 |
| Bio databases IDs | |
| Aliases | protein phosphatase 4, regulatory subunit 4 |
| Synonyms | 8430415E04Rik, CFAP14, KIAA1622, mKIAA1622, PP4R4, protein phosphatase 4 regulatory subunit 4, protein phosphatase 4, regulatory subunit 4, RGD1560932 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp4r4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- type 1 serine/threonine specific protein phosphatase inhibitor
- protein phosphatase regulator
- protein binding
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- basal bodies
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp4r4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phosphoprotein phosphatase activity
- regulation of protein serine/threonine phosphatase activity
- blastocyst hatching
Cellular Component
Where in the cell the gene product is active
- protein serine/threonine phosphatase complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity