Hnrnpl Gene Summary [Mouse]
Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in pronucleus. Is active in synapse. Is expressed in several structures, including brain; early conceptus; female reproductive system; sensory organ; and tail unsegmented mesenchyme. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpl |
| Official Name | heterogeneous nuclear ribonucleoprotein L [Source:MGI Symbol;Acc:MGI:104816] |
| Ensembl ID | ENSMUSG00000015165 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein L |
| Synonyms | C79783, D830027H13Rik, heterogeneous nuclear ribonucleoprotein L, HNRPL, L-protein, P/OKcl.14, Ribonucleoprotein l |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RRM-like domain
- hnRNP-L/PTB/hephaestus splicing factor family
- mRNA 3' UTR binding
- double-stranded DNA binding
- RNA recognition motif
- nucleic acid binding
- mRNA binding
- protein binding
- sequence-specific DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
role in cell
- proliferation
- differentiation
- growth
- expression in
- migration
- phosphorylation in
- cell movement
- response by
- alternative splicing by
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- ribonucleoprotein granule
- Cytoplasm
- cell surface
- perinuclear region
- ribosome
- polysomes
- nucleoplasm
- interchromatin granule clusters
- pronucleus
- synapse
- chromatin
- paraspeckle-like structures
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of RNA splicing
- RNA processing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA intronic binding
- RNA binding
- protein binding
- transcription regulatory region sequence-specific DNA binding
- mRNA binding