PPP4R4 Gene Summary [Human]
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | PPP4R4 |
| Official Name | protein phosphatase 4 regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:23788] |
| Ensembl ID | ENSG00000119698 |
| Bio databases IDs | |
| Aliases | protein phosphatase 4 regulatory subunit 4, cilia and flagella associated protein 14 |
| Synonyms | 8430415E04Rik, CFAP14, KIAA1622, mKIAA1622, PP4R4, protein phosphatase 4 regulatory subunit 4, protein phosphatase 4, regulatory subunit 4, RGD1560932 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP4R4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- type 1 serine/threonine specific protein phosphatase inhibitor
- protein phosphatase regulator
- protein binding
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- basal bodies
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP4R4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phosphoprotein phosphatase activity
- regulation of protein serine/threonine phosphatase activity
- blastocyst hatching
Cellular Component
Where in the cell the gene product is active
- protein serine/threonine phosphatase complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity