Akr1c18 Gene Summary [Mouse]
Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity. Acts upstream of or within parturition and progesterone catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; female reproductive system; and lung. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr1c18 |
| Official Name | aldo-keto reductase family 1, member C18 [Source:MGI Symbol;Acc:MGI:2145420] |
| Ensembl ID | ENSMUSG00000021214 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member C18 |
| Synonyms | 20-alpha-hydroxysteroid dehydrogenase, 20-α-hydroxysteroid dehydrogenase, Akr1c3, aldo-keto reductase family 1, member C18, aldo-keto reductase family 1, member C3, LOC171516, Prostaglandin F synthase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1c18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3(or 17)beta-hydroxysteroid dehydrogenase
- cortisone beta-reductase
- Aldo-keto reductase (AKR) superfamily
- retinal dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- ketosteroid monooxygenase
- 15-hydroxyprostaglandin-D dehydrogenase (NADP)
- 20alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase
- ketoreductase
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- retinol dehydrogenase
- geranylgeranyl reductase
- aldehyde reductase
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Akr1c18 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol