Akr1c3 Gene Summary [Rat]
Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity and aldose reductase (NADPH) activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Acts upstream of or within progesterone metabolic process. Located in cytosol. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr1c3 |
| Official Name | aldo-keto reductase family 1, member C3 [Source:RGD Symbol;Acc:708428] |
| Ensembl ID | ENSRNOG00000017531 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member C3 |
| Synonyms | 20-alpha-hydroxysteroid dehydrogenase, 20-α-hydroxysteroid dehydrogenase, Akr1c3, aldo-keto reductase family 1, member C18, aldo-keto reductase family 1, member C3, LOC171516, Prostaglandin F synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akr1c3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3(or 17)beta-hydroxysteroid dehydrogenase
- cortisone beta-reductase
- Aldo-keto reductase (AKR) superfamily
- retinal dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- ketosteroid monooxygenase
- 15-hydroxyprostaglandin-D dehydrogenase (NADP)
- 20alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase
- ketoreductase
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- retinol dehydrogenase
- geranylgeranyl reductase
- aldehyde reductase
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Akr1c3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol