Acot2 Gene Summary [Mouse]
Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process; long-chain fatty-acyl-CoA catabolic process; and response to hypoxia. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot2 |
| Official Name | acyl-CoA thioesterase 2 [Source:MGI Symbol;Acc:MGI:2159605] |
| Ensembl ID | ENSMUSG00000021226 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 2 |
| Synonyms | Acte, acyl-CoA thioesterase 2, Acyl-CoA Thioester Hydrolase 1, Mte1, MTE-I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acot2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix