Acot2 Gene Summary [Rat]
Enables long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including long-chain fatty-acyl-CoA catabolic process; response to epidermal growth factor; and response to hypoxia. Predicted to be located in mitochondrion. Used to study type 2 diabetes mellitus. Orthologous to human ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot2 |
| Official Name | acyl-CoA thioesterase 2 [Source:RGD Symbol;Acc:621055] |
| Ensembl ID | ENSRNOG00000010134 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 2 |
| Synonyms | Acte, acyl-CoA thioesterase 2, Acyl-CoA Thioester Hydrolase 1, Mte1, MTE-I |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acot2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix