Aoah Gene Summary [Mouse]
This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | Aoah |
| Official Name | acyloxyacyl hydrolase [Source:MGI Symbol;Acc:MGI:1350928] |
| Ensembl ID | ENSMUSG00000021322 |
| Bio databases IDs | |
| Aliases | acyloxyacyl hydrolase |
| Synonyms | 4930433E13RIK, ACYLOXYACYL HYDROLASE, RGD1560514 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aoah often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SGNH_hydrolase
- acyloxyacyl hydrolase
- Saposin-like type B, region 2
- calcium ion binding
- enzyme
- protein binding
- Saposin (B) Domains
- Putative metal-binding motif
- GDSL-like Lipase/Acylhydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atypical femur fracture
- psoriasis
- ocular sarcoidosis
- IgA nephropathy
- splenomegaly
- non-insulin-dependent diabetes mellitus
- hepatomegaly
- human immunodeficiency virus I infection
- scarlet fever
regulates
- fatty acid
- lipopolysaccharide
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aoah gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- lipopolysaccharide catabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- acyloxyacyl hydrolase activity