Aoah Gene Summary [Rat]
Predicted to enable acyloxyacyl hydrolase activity and calcium ion binding activity. Predicted to be involved in fatty acid metabolic process; lipopolysaccharide catabolic process; and negative regulation of inflammatory response. Predicted to act upstream of or within lipopolysaccharide metabolic process. Orthologous to human AOAH (acyloxyacyl hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aoah |
| Official Name | acyloxyacyl hydrolase [Source:RGD Symbol;Acc:1560514] |
| Ensembl ID | ENSRNOG00000054964 |
| Bio databases IDs | |
| Aliases | acyloxyacyl hydrolase |
| Synonyms | 4930433E13RIK, ACYLOXYACYL HYDROLASE, RGD1560514 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aoah often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SGNH_hydrolase
- acyloxyacyl hydrolase
- Saposin-like type B, region 2
- calcium ion binding
- enzyme
- protein binding
- Saposin (B) Domains
- Putative metal-binding motif
- GDSL-like Lipase/Acylhydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atypical femur fracture
- psoriasis
- ocular sarcoidosis
- IgA nephropathy
- splenomegaly
- non-insulin-dependent diabetes mellitus
- hepatomegaly
- human immunodeficiency virus I infection
- scarlet fever
regulates
- fatty acid
- lipopolysaccharide
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aoah gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- lipopolysaccharide catabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- acyloxyacyl hydrolase activity