Atg16l1 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in several processes, including autophagosome assembly; axonal transport; and defense response to virus. Acts upstream of or within macroautophagy; negative stranded viral RNA replication; and telencephalon development. Located in several cellular components, including autophagosome membrane; phagophore assembly site membrane; and sperm midpiece. Part of Atg12-Atg5-Atg16 complex. Is active in glutamatergic synapse. Is expressed in central nervous system and retina. Used to study inflammatory bowel disease 10. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to human ATG16L1 (autophagy related 16 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg16l1 |
| Official Name | autophagy related 16-like 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1924290] |
| Ensembl ID | ENSMUSG00000026289 |
| Bio databases IDs | |
| Aliases | autophagy related 16-like 1 (S. cerevisiae) |
| Synonyms | 1500009K01Rik, APG16L, ATG16, ATG16A, ATG16L, autophagy related 16-like 1, FLJ10035, FLJ22677, IBD10, WDR30 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg16l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- beta propeller
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- protein binding activity, bridging
- WD domain, G-beta repeat
- enzyme binding
- coiled-coil domain
- WD40
- enzyme
- protein binding
- identical protein binding
- Prefoldin subunit
- ubiquitin-like protein transferase activity
- WD40 repeats
- prefoldin
- intermediate domain
Pathways
Biological processes and signaling networks where the Atg16l1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- inflammatory bowel disease
- inflammatory bowel disease type 10
- non-insulin-dependent diabetes mellitus
- pediatric inflammatory bowel disease
- Crohn disease
- dextran sodium sulfate-induced colitis
- streptococcal pharyngitis
- ileitis
- complication
role in cell
- expression in
- accumulation in
- number
- apoptosis
- quantity
- formation
- formation in
- differentiation
- activation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cellular membrane
- lysosome
- Mitochondria
- axonemes
- cytosol
- lysosome membrane
- endosomal membrane
- sperm midpiece
- synapse
- autophagic vacuoles
- organelle membrane contact site
- clathrin-coated vesicles
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg16l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of autophagy
- protein localization to pre-autophagosomal structure
- protein transport
- defense response to virus
- hippocampus development
- C-terminal protein lipidation
- macroautophagy
- corpus callosum development
- microautophagy
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- pre-autophagosomal structure membrane
- endolysosome membrane
- Atg12-Atg5-Atg16 complex
- cytosol
- autophagic vacuole
- autophagic vacuole membrane
- axoneme
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- GTPase binding
- protein anchor
- small conjugating protein ligase activity