Auh Gene Summary [Mouse]
Enables RNA binding activity and enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Auh |
| Official Name | AU RNA binding protein/enoyl-coenzyme A hydratase [Source:MGI Symbol;Acc:MGI:1338011] |
| Ensembl ID | ENSMUSG00000021460 |
| Bio databases IDs | |
| Aliases | AU RNA binding protein/enoyl-coenzyme A hydratase |
| Synonyms | AU RNA binding methylglutaconyl-CoA hydratase, AU RNA binding protein/enoyl-coenzyme A hydratase, C77140, Enoyl-coenzyme A hydratase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Auh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- crotonase-like
- mRNA 3' UTR binding
- methylglutaconyl-CoA hydratase
- enzyme
- Enoyl-CoA hydratase/isomerase
- RNA binding
- enoyl-CoA hydratase
Pathways
Biological processes and signaling networks where the Auh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Auh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- leucine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- methylglutaconyl-CoA hydratase activity
- itaconyl-CoA hydratase activity
- enoyl-CoA hydratase activity
- mRNA 3'-UTR binding