Gtf2h2

Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in nucleotide-excision repair; regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to several human genes including GTF2H2 (general transcription factor IIH subunit 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtf2h2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gtf2h2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.