Hexb Gene Summary [Mouse]
Enables beta-N-acetylhexosaminidase activity and identical protein binding activity. Involved in several processes, including astrocyte cell migration; dermatan sulfate proteoglycan catabolic process; and glycosaminoglycan catabolic process. Acts upstream of or within several processes, including ganglioside catabolic process; penetration of zona pellucida; and sensory perception of sound. Located in extracellular space; membrane; and secretory granule. Is active in lysosome. Is expressed in several structures, including endocrine gland; eye; genitourinary system; hemolymphoid system; and nervous system. Used to study Sandhoff disease. Human ortholog(s) of this gene implicated in Sandhoff disease and spinal muscular atrophy. Orthologous to human HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hexb |
| Official Name | hexosaminidase B [Source:MGI Symbol;Acc:MGI:96074] |
| Ensembl ID | ENSMUSG00000021665 |
| Bio databases IDs | |
| Aliases | hexosaminidase B |
| Synonyms | beta HEXOSAMINIDASE, Beta-n-acetylglucosaminidase, ENC-1AS, HEL-248, HEL-S-111, HEXOSAMINIDASE B, hexosaminidase subunit beta, hexosaminidase subunit β, NA-beta-GASE, N Acetyl Beta Glucosaminidase, n-acetyl-b-glucosaminidase, N Acetyl β Glucosaminidase, Nag, NA-β-GASE, β HEXOSAMINIDASE, β-n-acetylglucosaminidase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hexb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 20, catalytic domain
- acetylglucosaminyltransferase
- enzyme
- protein binding
- beta-N-acetylglucosaminidase
- identical protein binding
- hexosaminidase
- Glycosyl hydrolase family 20, domain 2
- binding protein
- GH20_hexosaminidase
- beta-L-N-acetylhexosaminidase
- hydrolase
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Sandhoff disease
- adult Sandhoff disease
- hereditary disorder
- seizures
- gentamicin-induced renal injury
- juvenile Sandhoff disease
- infantile Sandhoff disease
- early onset hypertension
- growth failure
- paralysis
regulates
- TNF
- lipid
- Ca2+
- chondroitin sulfate B
- 18:1/16:0 lysobisphosphatidic acid
- 22:0 cholesteryl ester
- chondroitin sulfate E
- oligosaccharide
- gangliotriaosylceramide II3-sulfate
- lactosylceramide II3-sulfate
role in cell
- apoptosis
- quantity
- growth
- organization
- size
- degeneration
- abnormal morphology
- migration by
- accumulation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome fractions
- membrane fraction
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- lysosome
- lysosomal compartment
- acrosome
- cortical granules
- cytotoxic granule
- azurophil granules
- secretory granules
- phagosomes
- plasma
- late endosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hexb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- lipid storage
- male courtship behavior
- oligosaccharide catabolic process
- myelination
- positive regulation of transcription from RNA polymerase II promoter
- single fertilization
- ganglioside catabolic process
- sensory perception of sound
- skeletal system development
- chondroitin sulfate catabolic process
- locomotory behavior
- dermatan sulfate catabolic process
- glycosaminoglycan metabolic process
- astrocyte cell migration
- lysosome organization
- penetration of zona pellucida
- phospholipid biosynthetic process
- cellular calcium ion homeostasis
- neuron homeostasis
- maintenance of location in cell
- oogenesis
- neuromuscular process controlling balance
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- cortical granule
- extracellular vesicular exosome
- acrosomal vesicle
- azurophil granule
- membrane
- lysosomal lumen
- extracellular region
- azurophil granule lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- acetylglucosaminyltransferase activity
- beta-N-acetylhexosaminidase activity