Gpr65 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including activation of GTPase activity; positive regulation of stress fiber assembly; and response to acidic pH. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human GPR65 (G protein-coupled receptor 65). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr65 |
| Official Name | G-protein coupled receptor 65 [Source:MGI Symbol;Acc:MGI:108031] |
| Ensembl ID | ENSMUSG00000021886 |
| Bio databases IDs | |
| Aliases | G-protein coupled receptor 65 |
| Synonyms | Dig1, GPCR25, G protein-coupled receptor 65, hTDAG8, TDAG8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr65 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr65 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- breast carcinoma
- COVID-19
- neoplasia
- inflammatory bowel disease
- Parkinson disease
- Alzheimer disease
- acne
- experimental autoimmune encephalomyelitis
- colon carcinoma
- colon epithelial cancer
role in cell
- cell viability
- apoptosis
- migration
- production in
- formation
- activation in
- morphology
- assembly
- resorption by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cell surface
- cellular membrane
- endosomal membrane
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr65 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- positive regulation of stress fiber assembly
- apoptotic process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- response to acidity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity