GPR65 Gene Summary [Human]
Enables G protein-coupled receptor activity. Involved in several processes, including actin cytoskeleton reorganization; activation of GTPase activity; and positive regulation of stress fiber assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR65 |
| Official Name | G protein-coupled receptor 65 [Source:HGNC Symbol;Acc:HGNC:4517] |
| Ensembl ID | ENSG00000140030 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 65 |
| Synonyms | Dig1, GPCR25, G protein-coupled receptor 65, hTDAG8, TDAG8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR65 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR65 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- breast carcinoma
- COVID-19
- neoplasia
- inflammatory bowel disease
- Parkinson disease
- Alzheimer disease
- acne
- experimental autoimmune encephalomyelitis
- colon carcinoma
- colon epithelial cancer
role in cell
- cell viability
- apoptosis
- migration
- production in
- formation
- activation in
- morphology
- assembly
- resorption by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cell surface
- cellular membrane
- endosomal membrane
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR65 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- positive regulation of stress fiber assembly
- apoptotic process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- response to acidity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity